The decision usually breaks down along four axes: pathology, levels, anatomy, and what comes next.
Pathology. Single-level isthmic spondylolisthesis with radicular leg pain is a textbook MIS-TLIF case - the construct is small, the working corridor is friendly, and the recovery benefit is real. Adult degenerative scoliosis requiring 4-level reconstruction with sagittal correction is almost never the right MIS case - the deformity work needs direct visualization and the open exposure adds time but reduces complication risk.
Levels. One level: MIS is almost always worth considering. Two levels: still very reasonable, especially for isthmic or degenerative spondylolisthesis. Three levels or more: the operative time premium for MIS starts to exceed the recovery benefit, and most surgeons (including ours) default to open. Hybrid constructs - MIS at one level, open at an adjacent level - exist for specific cases.
Anatomy. Body habitus matters. Very high BMI can make the tubular retractor working depth unworkable. Prior posterior fusion with hardware in place limits the percutaneous corridor. Severe osteoporosis where the surgeon needs to feel the screw purchase by hand often steers toward open. Lateral approaches (LLIF/XLIF) require accessible psoas anatomy and are not options at L5-S1 because the iliac crest is in the way.
What comes next. A patient who needs to be back at a desk job in 3-4 weeks weights MIS heavily. A patient with a planned 6-month leave already arranged for a complex deformity has no functional benefit from chasing MIS at the expense of the right construct. The honest answer at your evaluation depends on your imaging, your exam, your body, and your goals.