There's no universal answer, but the decision breaks down along four axes: infection status, vascular status, offloading capacity, and patient circumstance.
Infection status. An actively infected ulcer — purulence, cellulitis, suspected deep abscess, or osteomyelitis — is not a TCC candidate. The cast hides the wound for a week at a time and we need eyes on an infection daily. Acute infection comes first: cultures, antibiotics, sometimes surgical drainage, occasionally debridement of infected bone. Once the infection is controlled, TCC becomes appropriate.
Vascular status. Healing requires blood flow. We check pulses, get an ankle-brachial index, and order vascular imaging when indicated. If you have significant peripheral arterial disease, no amount of offloading will heal the wound — you need vascular intervention first. Skipping that step is the most common reason a "non-healing ulcer" doesn't close.
Offloading capacity. Can the patient physically tolerate a TCC? Most can. Edge cases: severe COPD where the cast weight is a problem, profound balance issues where falls become a risk, end-stage renal disease with rapid fluid shifts that change cast fit week-to-week. For those patients, local care with the best removable offloading we can engineer is the right call.
Patient circumstance. Drivers (TCC on the right foot complicates driving), patients who work in water, patients who live alone with poor home support — all change the calculus. We talk through real life, not just the wound.